Congratulations to Dr. Emily Forbes on her acceptance into the Colorado Clinical and Translational Sciences Institute’s (CCTSI) Clinical Faculty Scholars Program (CFSP). This program enrolls up to five junior faculty members each year. The program helps young researchers obtain grant funding for their career growth or their first independent investigator-initiated project. Often these are K-awards or R-awards which are funded by the NIH. These can also be awards from large non-profit organizations. The CCTSI trains these budding researchers through guided project development, educational seminars, grant writing classes, and mentorship participation.
Dr. Forbes’s project will build a Neurogenetics database. The first goal will be to characterize genetic causes of Parkinson’s disease in the University of Colorado’s patient population. She will follow this group over time to see how they respond to treatment based on their genetic variant. She will build this database to include phenotypic (observable characteristics) and genotypic (genetic characteristics) information across different specialties in Neurology. This will lead to a department resource for genetics research. Her long-term aim is to develop a tool to advance fair and the best genetic testing for patients. This will also help to provide thorough genetic counseling. This tool will make clinical trials for disease-modifying treatments available to more patients and quicken the rate of developing new therapies. Additionally, it will widen the availability of clinical trials to patient populations.
Other Movement faculty alumni of the CFSP program include Dr. Michelle Fullard and Dr. Samantha Holden and former movement disorders faculty, Dr. Brian Berman, and Dr. Benzi Kluger.
Being part of a medical school means that in addition to seeing patients, our faculty are also involved in additional pursuits. One of these pursuits is conducting clinical research related to their field. Most research falls into two categories: clinical trials and investigator-initiated research. Clinical trials are a type of clinical research that aims to determine the safety and effectiveness of the medication, devices, and treatment regimens. Investigator-initiated research starts with new ideas that the researcher comes up with themself. The researcher then is responsible for creating a trial to test their idea and then carrying out the trial. All research must adhere to strict rules and regulations. You can read more about the research here.
Join Dr. Michael Korsmo as he gives updates on the current FDA-approved medications for Parkinson disease. During this talk, Dr. Korsmo will talk about newly approved medications and how they fit into the current scheme of pharmaceutical therapies available for Parkinson disease.
Please note that Dr. Korsmo will not be discussing therapies that are still in the research phases.
Written by Alex Baumgartner, MD
In a recent issue of the journal Movement Disorders, colleagues and I published a study examining the relationship between two of the most common ‘non-motor’ symptoms of Parkinson’s disease (PD): decreased sense of smell (olfactory dysfunction) and constipation. It has been known for some time that these symptoms often start several years or even decades before the typical ‘motor’ symptoms of PD, which include tremor, stiffness, and slow movement. Going along with this, accumulation of the abnormal protein alpha-synuclein, which is thought to play a critical role in the development of PD, have been found in the nasal passages and GI tracts of PD patients before it is found in the brain. This has led many to hypothesize that PD may actually begin in the nose or in the gut and spread from there to the brain.
We wanted to explore whether we could find evidence that for some people, PD begins in the nasal passages while in other people, it begins in the gut. We hypothesized that if people had PD originating in the nasal passages only, they would have only loss of smell and not constipation. On the other hand, if PD originated in the GI tract only, they would have constipation but not loss of smell. We looked at data from the Parkinson’s Progression Markers Initiative (PPMI), which collects information from patients who have recently been diagnosed with PD.
We found that at the time people are diagnosed with PD, they tend to have problems with smelling and constipation to similar degrees. That is, people with worse sense of smell also tend to have worse constipation, and those with minimal loss of smell tend to have mild constipation. This finding actually went against our hypothesis. There may be a few reasons for this. The first is that the time of diagnosis of PD (based on tremor, slowness, and stiffness) may be too late to detect a difference in smell and constipation. Even if PD begins in either the nose or the gut, symptoms in the other location may have already ‘caught up’ with the first. The second possible explanation is that PD may begin in both locations at about the same time. This is called the dual-hit hypothesis, and has gained popularity in recent years. In the future, we hope to expand our research to help elucidate where and when the earliest signs of Parkinson’s occur.
Sleep issues and fatigue are common among people with Parkinson’s disease. Sleep issues can include insomnia, daytime sleepiness, restless legs, and REM sleep behaviour disorder. Fatigue is a separate but related issue that often overlaps with daytime sleepiness. Join the Parkinson Association of the Rockies and Dr. Alexander Baumgartner, University of Colorado Movement Disorders Center, to discuss the issue of sleep and fatigue and some possible remedies.
Dr. Baumgartner, was born and raised in Lakewood, CO. He obtained his medical degree in Providence, RI and completed his residency training in Boston, serving as chief resident in his final year. He is excited to begin a 2-year fellowship in Movement Disorders in July 2020, and also to be returning home to Colorado.
Visit the registration website to reserve your spot today.
When we select fellows for our training program, they must be eligible to take these board examinations. This means they must meet all of the minimum requirements to take the exam by the start of their fellowship training. Fellows typically take the test towards the end of their first semester which is the earliest the test is offered.
Board certifications are important because they promote and assess the competence of physicians when beginning and throughout their careers. Board-certified physicians must provide proof that they are continuing their education through Continuing Medical Education credits and are recertified at set intervals throughout their career.
While board certifications are not required to practice medicine, they are an extra step many physicians choose to take. The certifications demonstrate the physicians are keeping up with the most recent advancements in their specialties and their desire to provide high-quality care to their patients. Board certifications are specific to each specialty and therefore maintain more specific standards to maintain certifcation.
All of the movement disorders specialists at the University of Colorado Movement Disorders Center are board-certified in neurology.
Say congratulations to our fellows if you see them in clinic!
The faculty and staff of the Movement Disorders Center has moved online for many things. Many of our upcoming events for Parkinson disease community have also been moved online. We miss meeting in person but have been able to continue our collaborations and work.
One of the great things we have found through these tough times is the ability to connect with other groups and organizations. We have been working virtually with groups throughout Colorado and throughout the country. Our community has access to more information and more resources.
Upcoming Events for Parkinson Disease | Movement Disorders Center
Dr. Drew Kern is hosting a webinar about Deep Brain Stimulation (DBS) for Essential Tremor and Parkinson disease. The webinar will be Thursday, May 21, 2020 at 10:00 AM MT.
Dr. Kern will talk about the DBS process, different products available, and the benefits and risks of surgery.
The webinar is free, but please register here before. After registering, you will get a confirmation email with instructions to join the webinar.
Upcoming Events for Parkinson Disease | Parkinson’s Foundation (PF)
Care Partner Summit
The Parkinson Foundation summit will take place virtually on Saturday, May 16th from 12:00 pm- 3:30 pm ET (10:00 am – 1:30 pm). This year’s Summit will focus on the unique journey of a care partner, with our theme: Planning for the Unpredictable Path of Parkinson’s Caregiving.
A timely topic during the COVID-19 pandemic, the speakers and care partners are ready to share their insight and encouragement to those caring for someone living with Parkinson’s disease (PD). We recognize the hard work that goes into caregiving and we want to create this space for them to share their life lessons, learn from each other and grow in their self-care skills.
The summit will be online only, and individuals may register for English or Spanish. The Care Partner Summit will be focused on the following topics:
- Cognitive Changes
- Mental Health
- Practical Planning
PD Health @ Home
During this challenging and often isolating time of social distancing, now more than ever PF recognizes the importance for people within the Parkinson’s community to stay active, connect with each other, and receive support no matter their physical location.
Visit Parkinson.org/PDHealth for a full list of events. Participants can register for virtual community engagement events of interest and put them on their calendars. You can join PF for these upcoming events:
Take Time Thursdays
Choose from several virtual events taking place across local chapters. Engage with a PD expert on the topics that matter most to you ― from exercise, nutrition, stress management, and more. Sign up now. View past events.
This PD-tailored 10-part fitness series will feature a new focus every week, from balance to coordination, posture, and more. Watch each 12-minute session from home as many times as you wish. Watch now!
Consult with your healthcare team before beginning any new physical activity, including online exercise classes and programs. The Parkinson’s Foundation is in no way liable or responsible for injuries sustained from online classes.
PD Health @ Home will be held from April 6 to June 11. Find all PD Health @ Home programs here. Register for the events that interest you and put them on your calendar. New to virtual events? Read our guide here.
Resources That are Always Available
The Parkinson’s Foundation is dedicated to empowering the PD community through education. Below are additional resources always available to you:
- PD Conversations
- Parkinson’s Today Blog
- Bilingual Helpline 1-800-4PD-INFO (473-4636) Weekdays 9 a.m. to 8 p.m. ET.
- Follow us on Facebook
- Substantial Matters Podcast
- Expert Briefing Webinars
Stay healthy and well!